TABLE 2.
Number of A. fumigatus organisms in the lungs of rats with experimental IPA
| Treatment | No. of aspergilli (log10 CFU/g) at the following times postinoculationa:
|
|
|---|---|---|
| 24 h | 72 h | |
| Control | 3.95 ± 0.39 | 4.53 ± 0.31 |
| NS-718 | 3.11 ± 0.35b | 1.90 ± 0.24bc |
| D-AmB | 3.43 ± 0.54 | 1.87 ± 0.30bc |
| L-AmB | 3.91 ± 0.56 | 3.55 ± 0.31b |
a
Data are the mean ± standard deviation number of aspergilli in the lungs at 24 and 72 h after inoculation into rats treated with the indicated forms of AmB for 3 days. A dose of 3.0 mg of each form per kg was injected intravenously into each of six rats in each group.
b
P < 0.05 compared with the results for the respective control rats.
c
P < 0.05 compared with the results for the respective L-AmB-treated rats (Sheffe’s test).