TABLE 3.

Serum biochemical profiles for rats treated for 8 days by injection of NS-718, L-AmB, or D-AmB^a

Drug	No. of rats	SGOT level (mU/ml)	SGPT level (mU/ml)	BUN level (mg/ml)	Creatinine level (mg/ml)
Control	6	437 ± 209	419 ± 220	11.3 ± 2.8	0.14 ± 0.04
NS-718	6	581 ± 247	568 ± 231	34.9 ± 13.2b	0.30 ± 0.10c
D-AmB	5	388 ± 185	314 ± 149	63.3 ± 24.1b	0.40 ± 0.07c
L-AmB	5	660 ± 375	651 ± 287	16.7 ± 4.0c	0.17 ± 0.06

^aData are expressed as means ± standard deviations. 

^bP < 0.05, compared with the results for the respective control rats (Welch test). 

^cP < 0.05 compared with the results for the respective control rats (Student’s t test).