FIG. 2.

Efficacy of various antibiotic regimens for treatment of experimental endocarditis due to E. faecalis BM4275 (Vm^r Te^s). Vegetation homogenates were plated on agar to enumerate surviving bacteria and on agar containing teicoplanin (16 μg/ml) or gentamicin (32 μg/ml) to enumerate mutants resistant to teicoplanin or gentamicin, respectively. Log₁₀ CFU per gram of vegetation are shown for individual rabbits. For the gentamicin, teicoplanin, and gentamicin-plus-vancomycin regimens, animals were assigned to two groups based on the presence or absence of mutants. The mean ± standard deviation of log₁₀ CFU per gram was calculated for the two groups and for all rabbits.