Table 2.

Variation in agreement between National Comprehensive Cancer Network (NCCN) and Assess Your Risk (AYR) by race, ethnicity, and age group.

			AYR compared with NCCN criteria only
			Totala, n (%)		True positive, n		True negative, n		Sensitivity (%)		Specificity, (%)	PPVb (%)		NPVc (%)		P valued
Overall			117,595 (100)		72,072		40,880		100.00		89.80	93.95		100.00		<.001
Race and ethnicity
	White	82,128 (69.83)		52,078		26,994		100.00		89.83		94.46	100.00		<.001
	African American	3886 (3.3)		2125		1608		100.00		91.31		93.28	100.00		<.001
	Asian	3187 (2.71)		1311		1612		100.00		85.93		83.24	100.00		<.001
	Other	17,614 (14.97)		10,803		6086		100.00		89.36		93.71	100.00		<.001
	Ashkenazi Jewish	584 (0.49)		373		187		100.00		88.63		93.95	100.00		<.001
	Hispanic or Latina	10,196 (8.67)		5382		4393		100.00		91.25		92.75	100.00		<.001
Age group (years)
	18-29	65,352 (55.57)		41,126		21,936		100.00		90.55		94.73	100.00		<.001
	30-39	28,541 (24.27)		17,475		9694		100.00		87.60		92.72	100.00		<.001
	40-49	1590 (1.35)		9170		5736		100.00		89.35		93.06	100.00		<.001
	50-64	7167 (6.09)		3832		3068		100.00		91.99		93.49	100.00		<.001
	≥65	945 (0.8)		469		446		100.00		93.70		93.99	100.00		<.001

^aSample size excluded women with a history of genetic testing in the high risk category (n=6342), no personal history of cancer (n=7056), or unknown family history (n=19,138). These categories were not mutually exclusive, and 26,062 were excluded from the analysis.

^bPPV: positive predictive value.

^cNPV: negative predictive value.

^dP value was calculated using McNemar test.