Table 3.
Assess Your Risk (AYR) compared with National Comprehensive Cancer Network (NCCN) criteria plus polycystic ovary syndrome, childhood radiation, and abnormal breast biopsy
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AYR full criteria compared with NCCN criteria | ||||||||
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Totala, n (%) | True positive, n | True negative, n | Sensitivity (%) | Specificity (%) | PPVb (%) | NPVc (%) | P valued | |
| Overall | 117,595 (100) | 76,714 | 40,880 | 100.00 | 100.00 | 100.00 | 100.00 | .32 | |
| Race and ethnicity | |||||||||
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White | 82,128 (69.83) | 55,134 | 26,994 | 100.00 | 100.00 | 100.00 | 100.00 | —e |
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African American | 3886 (3.3) | 2277 | 1608 | 100.00 | 99.94 | 99.96 | 100.00 | .32 |
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Asian | 3187 (2.71) | 1575 | 1612 | 100.00 | 100.00 | 100.00 | 100.00 | — |
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Other | 17,614 (14.98) | 11,528 | 6086 | 100.00 | 100.00 | 100.00 | 100.00 | — |
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Ashkenazi Jewish | 584 (0.49) | 397 | 187 | 100.00 | 100.00 | 100.00 | 100.00 | — |
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Hispanic or Latina | 10,196 (8.67) | 5803 | 4393 | 100.00 | 100.00 | 100.00 | 100.00 | — |
| Age group (years) | |||||||||
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18-29 | 65,352 (55.57) | 43,416 | 21,936 | 100.00 | 100.00 | 100.00 | 100.00 | — |
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30-39 | 28,541 (24.27) | 18,846 | 9694 | 100.00 | 99.99 | 99.99 | 100.00 | .32 |
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40-49 | 15,590 (13.26) | 9854 | 5736 | 100.00 | 100.00 | 100.00 | 100.00 | — |
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50-64 | 7167 (6.09) | 4099 | 3068 | 100.00 | 100.00 | 100.00 | 100.00 | — |
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≥65d | 945 (8.03) | 499 | 446 | 100.00 | 100.00 | 100.00 | 100.00 | — |
aSample size excluded women with a history of genetic testing in the high risk category (n=6342), no personal history of cancer (n=7056), or unknown family history (n=19,138). These categories were not mutually exclusive, and 26,062 were excluded from the analysis.
bPPV: positive predictive value.
cNPV: negative predictive value.
dP value was calculated using McNemar test.
eNo discordant pairs between groups where all measures are 100.00.