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Schematic presentation of the IE and IE′ determinations applied to the kinetics of killing and regrowth of E. coli exposed to trovafloxacin (AUC/MIC = 58 [μg · h/ml]/[μg/ml]). IE (or IE′) describes the dashed area between the control growth (thin lines) and killing and regrowth (bolded lines) curves at the same cutoff level of 1011 CFU/ml (IE determination) or at different cutoff levels (IE′ determination).
