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Formulation variables and their responses used to optimize CEP SNEDDS.
| Variables | Levels | ||
|---|---|---|---|
| Low (−) | Medium (0) | High (+) | |
| A = Oil (%, w/w) | 5 | 16.5 | 28 |
| B = Surfactant (%, w/w) | 32 | 55 | 78 |
| C = Co-surfactant (%, w/w) | 8 | 30 | 52 |
| Responses | Goals | ||
| Y1 = Globule size (nm) | |||
| Y2 = Transmittance (%) | |||
| Y3 = Emulsification time (s) | |||
Oil (Lauroglycol 90); Surfactant (Poloxamer 188); Co-surfactant (Transcutol HP).
