Table 5.
Pharmacokinetic parameters of CEP-SNEDDS (Opt-F3) and CEP dispersion after single-dose oral administration. The study performed with six rats in each group and data given as mean ± SD.
| Pharmacokinetic Parameters |
CEP-SNEDDS-opt (Opt-F3) | CEP Dispersion |
|---|---|---|
| Cmax (ng/mL) | 7.69 ± 0.72 | 4.69 ± 0.57 |
| Tmax (h) | 4 | 2 |
| AUC0–24 (µ·h/mL) | 71.37 ± 4.28 | 20.50 ± 3.76 |
| AUC0–∞ (µ·h/mL) | 77.31 ± 4.87 | 20.73 ± 3.76 |
| AUMC0–24 (µg·h2/mL) | 534.50 | 86.90 |
| AUMC0–∞ (µg·h2/mL) | 727.70 | 93.33 |
| Half life (t1/2 h) | 5.91 ± 0.15 | 1.24 ± 0.12 |
| Elimination rate constant (h−1) | 0.12± 0.05 | 0.21 ± 0.03 |
| MRT (h) | 9.41 ± 0.45 | 4.50 ± 0.5 |