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Biocatalytic process for N-hydroxy-cytidine synthesis. (a) In situ crystallization of 4 in reactions catalyzed by CD1.3 leads to product enrichment. Reaction conditions: 750 mM 2, 7.5 μM CD1.3, 10% NH2OH (∼3 M, pH 7), 4 °C. (b) HPLC trace of the product isolated from the biotransformation described in (a). (c) Stacked 1H NMR traces of 4, commercial standard (top), and the product isolated from the biotransformation described in (a) (bottom).
