TABLE 2.

Therapeutic effects of KRM, MBST, and KRM-MBST against MAC infection in mice observed at 8 weeks after infection^a

Drug(s)	Dose(s) (mg/kg)	Mean log CFU ± SEMb
		Lungs		Spleen
		Day 1	Week 8	Day 1	Week 8
None	0	4.12 ± 0.07	7.03 ± 0.12	5.00 ± 0.14	7.93 ± 0.11
KRM	20	NDc	5.20 ± 0.06d	ND	7.12 ± 0.07d
MBST	50	ND	7.02 ± 0.11	ND	7.85 ± 0.08
KRM + MBST	20 + 50	ND	4.79 ± 0.09def	ND	6.89 ± 0.08de

^aMice infected i.v. with MAC N-444 (10⁷ CFU) were given or not given the indicated agents by gavage either once weekly (KRM) or once daily five times per week (MBST) from day 1 for up to 8 weeks. 

^bThere were five mice per regimen. 

^cND, not determined. 

^dSignificantly smaller than the value of untreated control mice (P < 0.01 by Bonferroni’s multiple t test). 

^eSignificantly smaller than the value of mice given MBST alone (P < 0.01 by Bonferroni’s multiple t test). 

^fThe difference from the values of mice given KRM alone was almost significant (P < 0.07) in Bonferroni’s multiple t test. Moreover, this difference was assessed as statistically significant by the Mann-Whitney test (P < 0.05).