Table III.

Single locus analysis (crude and adjusted for age and sex) for association between SCFD1 rs10139154 and ALS, in co-dominant, dominant, recessive, overdominant and log-additive mode.

		Univariate		Multivariate
Mode	Genotype	OR (95% CI)	P-value	OR (95% CI)	P-value
Co-dominant	C/C	1.00	0.7	1.00	0.44
	C/T	0.93 (0.57-1.51)		0.77 (0.38-1.54)
	T/T	0.75 (0.38-1.46)		0.57 (0.23-1.39)
Dominant	C/C	1.00	0.56	1.00	0.28
	C/T-T/T	0.87 (0.55-1.38)		0.70 (0.37-1.33)
Recessive	C/C-C/T	1.00	0.43	1.00	0.3
	T/T	0.78 (0.42-1.45)		0.64 (0.28-1.48)
Overdominant	C/C-T/T	1.00	0.99	1.00	0.78
	C/T	1.00 (0.63-1.58)		0.91 (0.48-1.73)
Log-additive	-	0.88 (0.64-1.21)	0.42	0.76 (0.49-1.16)	0.2

SCFD1, Sec1 family domain containing 1; ALS, amyotrophic lateral sclerosis; CI, confidence interval; OR, odds ratio.