Table IV.
Single locus analysis (crude and adjusted for age and sex) for association between SCFD1 rs10139154 and ALS, based on the site of disease onset (bulbar or limbs), in co-dominant, dominant, recessive, overdominant and log-additive modes.
| Bulbar onset | Limb onset | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|
||||||||
| Univariate | Multivariate | Univariate | Multivariate | ||||||
| Mode | Genotype | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value |
| Co-dominant | C/C | 1.00 | 0.39 | 1.00 | 0.16 | 1.00 | 0.35 | 1.00 | 0.35 |
| C/T | 1.37 (0.61-3.11) | 1.34 (0.40-4.46) | 0.63 (0.32-1.21) | 0.54 (0.23-1.26) | |||||
| T/T | 0.60 (0.16-2.29) | 0.28 (0.04-1.72) | 0.92 (0.41-2.07) | 0.74 (0.27-2.05) | |||||
| Dominant | C/C | 1.00 | 0.73 | 1.00 | 0.91 | 1.00 | 0.26 | 1.00 | 0.19 |
| C/T-T/T | 1.15 (0.52-2.52) | 0.94 (0.30-2.92) | 0.71 (0.39-1.28) | 0.60 (0.28-1.29) | |||||
| Recessive | C/C-C/T | 1.00 | 0.25 | 1.00 | 0.065 | 1.00 | 0.74 | 1.00 | 0.98 |
| T/T | 0.50 (0.14-1.77) | 0.23 (0.04-1.23) | 1.14 (0.53-2.43) | 0.99 (0.39-2.52) | |||||
| Overdominant | C/C-T/T | 1.00 | 0.26 | 1.00 | 0.21 | 1.00 | 0.15 | 1.00 | 0.18 |
| C/T | 1.56 (0.72-3.35) | 1.99 (0.67-5.90) | 0.64 (0.34-1.19) | 0.59 (0.27-1.30) | |||||
| Log-additive | - | 0.91 (0.53-1.58) | 0.75 | 0.66 (0.29-1.46) | 0.29 | 0.89 (0.59-1.33) | 0.56 | 0.80 (0.49-1.32) | 0.38 |
SCFD1, Sec1 family domain containing 1; ALS, amyotrophic lateral sclerosis; CI, confidence interval; OR, odds ratio.