Table V.

Single locus analysis (crude and adjusted for sex) for association between SCFD1 rs10139154 and AAO of ALS, in co-dominant, dominant, recessive, overdominant and log-additive mode.

Mode	Genotype	Mean (SE)	Difference (95% CI)	Univariate P-value	Multivariate P-value
Co-dominant	C/C	63.22 (1.5)	0.00	0.7	0.68
	C/T	64.75 (1.32)	1.53 (−2.38 to 5.43)
	T/T	63.05 (2.44)	−0.18 (−5.77 to 5.42)
Dominant	C/C	63.22 (1.5)	0.00	0.55	0.58
	C/T-T/T	64.33 (1.16)	1.11 (−2.54 to 4.75)
Recessive	C/C-C/T	63.97 (1.00)	0.00	0.73	0.67
	T/T	63.05 (2.44)	−0.92 (−6.17 to 4.33)
Overdominant	C/C-T/T	63.18 (1.27)	0.00	0.4	0.39
	C/T	64.75 (1.32)	1.57 (−2.09 to 5.23)
Log-additive	—	—	0.33 (−2.26 to 2.93)	0.8	0.85

SCFD1, Sec1 family domain containing 1; ALS, amyotrophic lateral sclerosis; AAA, age at onset; CI, confidence interval; SE, standard error.