Fabre 1987.

Methods	1. Randomized 2. Double blind 3. 2 parallel groups: ‐Buspirone 10‐50mg/d ‐Diazepam 10‐50mg/d 4. Duration: 4 weeks with a single‐blind lacebo for four to seven days prior 5. Analysis: Analysis of variance technique; all patients considered evaluable for safety and those who completed at least seven days were considered evaluable for efficacy
Participants	1. Diagnosis: GAD (DSM‐III) 2. N = 156 3. Age (% 18‐40, >40) ‐Buspirone (89,11) ‐Diazepam (85, 15) Sex: 47% females Setting: outpatients History: escluded any clinically significant reexisting kidney, liver, or cardiovascular disease, abnormal physical exam, laboratory studies or electrocardiograms, psychosis, borderline states, severe behvior disorders, substance abuse, or serious psychosomatic disorders
Interventions	1. Buspirone (N = 88) 2. Diazepam (N = 33)
Outcomes	1. dropout rates 2. HAM‐A 3. HAM‐D 4. CGI 5. Lipman‐Rickels Symptoms Checklist 6. Sleep Evaluation Questionnaire 7. Patient's Global Impressions 8. Profile of Mood States
Notes	(a) HAM‐A and CGI not entered into final analysis as data not available
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear