Lader 1998.

Methods	1. Randomized 2. Double blind 3. Three parallel groups ‐ placebo ‐ hydroxyzine 50 mg/d ‐ Buspirone 20 mg/d) 4. Duration: 4 weeks with 7 day run‐in period with single‐blind placebo prior 5. Analysis: LOCF
Participants	1. Diagnosis: GAD (DSM‐IV) 2. N = 244 3. Age (mean): placebo = 40 (11) buspirone: 41 (12) hydroxyzine: 42 (11) Sex: 69.3% females Setting: outpatients History: excluded any significant psychiatric disorder other than GAD
Interventions	1. Placebo (N = 81) 2. Hydroxyzine (N = 81) 3. Buspirone (N = 82)
Outcomes	1. dropout rates 2. HAM ‐A 3. CGI scores 4. Montgomery‐Asberg Depression rating Scale 5. Ferreri Anxiety Rating Diagram 6. Echelle Dyscontrole Comportemental (EDC) 7. Hospital Anxiety and Depression Scale 8. Tyrer Withdrawal Symptom Scale
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear