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. 2006 Jul 19;2006(3):CD006115. doi: 10.1002/14651858.CD006115

Pecknold 1985.

Methods 1. Randomized
2. Double blind
3. Three parallel groups
‐ placebo
‐ Diazepam 5‐40 mg/d
‐ Buspirone 5‐40 mg/d)
4. Duration: 4 weeks with seven day washout period with placebo prior
5. Analysis: Two‐Way ANOVA and Cochran‐Mantel‐Haenszel test
Participants 1. Diagnosis: GAD (DSM‐III)
2. N = 60
3. Age:
Buspirone = 34.71
Diazepam = 35.81
Placebo = 35.33
Sex: 65% females
Setting: outpatients
History:
excluded any significant psychiatric disorder other than GAD
Interventions 1. Placebo (N = 18)
2. Diazepam (N = 21)
3. Buspirone (N = 21)
Outcomes 1. dropout rates
2. SCL‐56
3. HAM ‐A
5. CGI
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment (selection bias) Unclear risk B ‐ Unclear