Pecknold 1985.
Methods | 1. Randomized 2. Double blind 3. Three parallel groups ‐ placebo ‐ Diazepam 5‐40 mg/d ‐ Buspirone 5‐40 mg/d) 4. Duration: 4 weeks with seven day washout period with placebo prior 5. Analysis: Two‐Way ANOVA and Cochran‐Mantel‐Haenszel test |
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Participants | 1. Diagnosis: GAD (DSM‐III) 2. N = 60 3. Age: Buspirone = 34.71 Diazepam = 35.81 Placebo = 35.33 Sex: 65% females Setting: outpatients History: excluded any significant psychiatric disorder other than GAD |
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Interventions | 1. Placebo (N = 18) 2. Diazepam (N = 21) 3. Buspirone (N = 21) |
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Outcomes | 1. dropout rates 2. SCL‐56 3. HAM ‐A 5. CGI |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment (selection bias) | Unclear risk | B ‐ Unclear |