Pecknold 1989.

Methods	1. Randomized 2. Double blind 3. Three parallel groups ‐ placebo ‐ Diazepam 10‐40 mg/d ‐ Buspirone 10‐40 mg/d) 4. Duration: 4 weeks with seven day washout period prior 5. Analysis: ANOVA and Cochran‐Mantel‐Haenszel test
Participants	1. Diagnosis: GAD (DSM‐III) 2. N = 125 3. Age: mean and range: Diazepam = 35 Buspirone 35 placebo: 34.1 4.Sex: 64% females 5. Setting: outpatients 6. History: excluded any significant psychiatric disorder other than GAD
Interventions	1. Placebo (N = 40) 2. Diazepam (N = 43) 3. Buspirone (N = 42)
Outcomes	1. dropout rates 2. SCL‐56 3. HAM ‐A 4. Global Psychopathology Rating
Notes	(a) Supported by Brystol Meyers Squibb (b) HAM‐A not included in analysis secondary to SDs not being reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear