Ramchandran 1990.

Methods	1. Randomized 2. Double blind 3. Two parallel groups: ‐Buspirone 15mg/d ‐Diazepam 15mg/d 4. Duration: 4 weeks with one week washout period prior 5. Analysis: Data on continuous variables were subjected to Student's t test and the categorical data was analyzed statistically using either the chi‐square test or Fisher's exact probabilty test
Participants	1. Diagnosis: GAD (DSM‐III) 2. N = 80 3. Age (mean and SE): Buspirone 25.8 (1.53) Diazepam 28.0 (1.31) Sex: 25.5% females Setting: outpatients History: excluded any significant psychiatric disorder other than GAD
Interventions	1. Buspirone (N = 40) 2. Diazepam (N = 40)
Outcomes	1. dropout rates 2. HAM‐A 3. HAM‐D 4. Lipman‐Rickets symptom check list 5. Profile of mood states 6. Raskin scale for depression 7. Covi scale for anxiety
Notes	(a) HAM‐A not entered into final analysis as means and SDs not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear