. 2022 Feb;72(1):22–29. doi: 10.30802/AALAS-CM-21-000087

Table 2.

CBC counts of IVA-infected ferrets that received buprenorphine

Cell type (reference interval; ×1000/µL)¹⁹	Time (d) after inoculation	Cell count (×1000/µL; mean ± 1 SD)^a
Cell type (reference interval; ×1000/µL)¹⁹	Time (d) after inoculation	Buprenorphine on days 0–4	Buprenorphine on days 5–9	Saline controls
WBC (3.0–16.7)	0	6.7 ± 1.4	4.1 ± 0.9	6.1 ± 1.3
	3	8.0 ± 1.2^b	5.5 ± 0.7	7.0 ± 0.6^b
	7	9.3 ± 0.9	7.0 ± 0.9	8.9 ± 0.8
	14	6.2 ± 4.1	5.5 ± 1.5	5.3 ± 0.5
Lymphocytes (0.6–10.5)	0	4.2 ± 1.3	2.6 ± 0.8	3.4 ± 1.0
	3	4.0 ± 1.0^b	2.9 ± 0.3^c	3.7 ± 1.4^b,c
	7	3.2 ± 1.3	2.8 ± 0.8	4.2 ± 0.9
	14	3.9 ± 0.1	2.9 ± 1.6	3.3 ± 0.5
Neutrophils (0.9–7.4)	0	2.0 ± 1.3	1.2 ± 0.2	2.3 ± 0.6
	3	3.7 ± 0.9	2.4 ± 0.4	3.1 ± 0.8
	7	5.6 ± 0.9^b,c	3.7 ± 1.1^b	4.0 ± 1.2^c
	14	1.9 ± 1.1	2.4 ± 0.7	1.6 ± 0.2
Monocytes (0.0–0.5)	0	0.1 ± 0.1	0.1 ± 0.0	0.2 ± 0.0
	3	0.1 ± 0.1	0.1 ± 0.0	0.1 ± 0.0
	7	0.3 ± 0.2	0.3 ± 0.2	0.3 ± 0.2
	14	0.2 ± 0.1	0.1 ± 0.1	0.1 ± 0.1
Eosinophils (0.0–0.7)	0	0.3 ± 0.2	0.2 ± 0.1	0.2 ± 0.1
	3	0.2 ± 0.1	0.1 ± 0.0	0.2 ± 0.0
	7	0.2 ± 0.2	0.2 ± 0.1	0.3 ± 0.1
	14	0.2 ± 0.2	0.1 ± 0.0	0.2 ± 0.1
Basophils (0.0–0.2)	0	0.0 ± 0.1	0.5 ± 1.0	0.0 ± 0.0
	3	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0
	7	0.0 ± 0.0	0.3 ± 0.6	0.0 ± 0.0
	14	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0

^{^a}

Values are from 4 ferrets per group, except for group 3, day 3 (n = 3 due to sample coagulation in one specimen prior to analysis). Significant (P < 0.05) between-group differences in WBC, lymphocytes, and neutrophils over time were determined through 2-way ANOVA with the Tukey posttest; similar superscript letters indicate significant differences between groups according to day.