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. 2021 Dec 23;2:757384. doi: 10.3389/fpain.2021.757384

Table 2.

Delayed regression increase (in Hyper) and decrease (in Hypo) for ACC, PO and PHG.

Brain area Coordinates Local peak t-value
x y z
Increase in Hyper associated with PO
ACC −10 34 24 3.56
Anterior Insula (aINS) −38 14 −6 4.52
Orbitofrontal cortex (OFC) 18 24 −20 4.79
Nucleus Accumbens (NAcc) 10 6 −10 4.89
Decrease in Hypo associated with PO
ACC 6 26 38 5.47
−4 42 24 5.05
6 20 30 5.00
8 10 44 4.26
−10 14 34 3.91
Posterior Insula (pINS) −40 −26 6 5.68
−36 −22 16 4.56
Thalamus 12 −16 10 6.30
Putamen 26 2 6 4.54
Globus Pallidus −10 0 0 5.71
Medial prefrontal cortex 8 50 −2 4.53
−8 50 2 4.69
M1 −28 −24 62 4.64
Increase in Hyper associated with aMCC
ACC 0 +38 16 5.38
−10 44 12 4.45
Hippocampus (26–38 4 t = 4.39) 26 −38 4 4.39
Decrease in Hypo associated with aMCC
ACC −12 40 28 5.30
−14 34 18 4.66
12 10 44 4.46
−14 26 28 4.21
−4 14 36 4.17
Anterior mid cingulate cortex (aMCC) −10 −10 46 4.47
pINS −36 −22 16 5.39
aINS −32 −22 16 5.39
S1 −16 −40 70 4.88
PCC −6 −26 46 5.50
M1 −30 −24 64 5.33
SMA −6 2 60 5.14
MPFC −12 48 2 5.01
−4 44 −6 4.66
Caudate 16 4 18 3.78
Putamen 28 2 8 5.37
−26 8 −2 5.74
OFC 2 58 −14 8.00
PAG −2 −24 −8 4.51
0 −34 −12 4.09
Increase in Hyper associated with PHG
ACC 0 20 22 4.68
−2 38 16 5.99
10 40 16 5.71
pINS −38 −10 12 3.52
Medial prefrontal cortex 0 52 4 4.79
Periaqueductal gray −20 −34 −16 4.00
Caudate 10 16 8 5.69
−8 14 10 5.00
8 2 12 4.78
Orbitofrontal cortex −2 20 −26 5.14
0 62 −18 7.28
Decrease in Hypo associated with PHG
S1 −14 −36 74 6.31
ACC −8 44 28 5.05
6 32 22 3.45
aMCC −8 2 44 4.09
−2 −10 44 3.69
pINS −34 −20 18 3.71
SMA −2 −10 44 3.69
DLMPFC −8 44 28 5.05
PCC 18 −56 34 5.18
−8 −38 36 4.33
Putamen −26 4 0 4.34
26 12 −8 4.32
OFC 12 24 −30 6.88
10 10 −22 5.47
−8 50 −14 5.27
−10 52 −14 4.55

All effects are reported at FDR q = 0.05.