Table 2.

Subgenual anterior cingulate cortex (sgACC) functional connectivity in carpal tunnel syndrome chronic pain patients and healthy controls: Main findings.

Contrast	sgACC	Z	p	MNI coordinates			Brain region
				x	y	z
Analysis 1. All CTS vs. HC (n = 50)
HC > CTS	L	4.19	0.00114	−14	60	18	Left frontal pole, pre-frontal cortex
	L	3.31	0.0133	−54	−26	−12	Left middle temporal gyrus
	R	4.9	1.2e-07	−48	14	−28	Left temporal pole
W > M (effect of sex)	L	4.53	0.0147	−30	66	6	Left frontal pole
	L	4.58	0.0323	26	40	−18	Right frontal pole, orbitofrontal cortex
	R	4.57	0.001	−34	64	0	Left frontal pole
	R	4.17	0.00175	26	42	−16	Right frontal pole, orbitofrontal cortex
M > W (effect of sex)	R	3.33	0.0484	−40	−30	18	Parietal operculum
Analysis 2. Sex disaggregated, men only (n = 14)
HC > CTS	L	4.23	0.016	−26	60	28	Left frontal pole
	R	4.52	7.4e-05	−24	58	26	Left frontal pole
	R	4.57	0.001	−50	−8	−28	Inferior temporal gyrus, middle temporal gyrus
	R	3.7	0.0138	−6	−14	56	Supplementary motor area
	R	3.23	0.0364	−44	8	36	Middle frontal gyrus
Analysis 4. Pre vs. post-op CTS (n = 17)
Pre > Post	L	4.74	1.85e-06	20	20	−14	Right orbitofrontal cortex, right putamen, right caudate
	L	3.45	0.00047	−22	32	−12	Left orbitofrontal cortex, left caudate
	L	3.72	0.036	−38	−64	−58	Left cerebellum
	R	3.83	0.00733	−38	−62	−58	Left cerebellum
	R	4.12	0.0472	44	0	58	Premotor cortex, middle frontal gyrus
Post > Pre	R	3.73	2.8e-06	22	−70	20	Cuneus, precuneus
	R	3.98	0.00484	−36	−16	10	Left posterior insula, central opercular cortex, Heschl's gyrus

Peak MNI coordinates, Z, and p-values are reported for significant clusters found in the sgACC seed-to-voxel whole brain functional connectivity analyses, comparing carpal tunnel syndrome (CTS) patients (n = 25) and healthy controls (HCs) (n = 25), as well as the sex-disaggregated (n = 14) and CTS pre vs. post-op (n = 17) seed-to-voxel whole brain analyses. Thresholded at p < 0.05 (FWE-corrected for multiple comparisons). W, women; M, men.