Table 5. A cross-section of research reports on micronized particles using discrete SCF technology.

SCF Process	API	Purpose	Highlight	Ref
DELOS	ibuprofen and naproxen	Micronization and determination of solubility	Ibuprofen showed same solubility profile, both in CO2-expanded ethanol and CO2–expanded acetone mixtures; whereas the naproxen solubility was greatly dependent on the nature of the solvent i.e. high in CO2–expanded ethanol.	[88]
RESOLV	Gambogic acid	Nanoparticles of gambogic acid were prepared to improve solubility.	Results outlined successfully preparation of nanosuspension of gambogic acid. Extended solubility data was correlated with density-based models that suggested enhanced bioavailability and antineoplastic efficacy of nanosized gambogic acid.	[89]
DELOS	Phytosterol	Nanonization and decrease crystallinity of phytosterol to modify solubility	Phytosterol nanoparticles were formulated through fast cooling, The crystallinity of the impregnated phytosterols was found to decrease in comparison to the pure phytosterol that modified water solubility.	[90]
RESOLV	Poly (l-lactide) (PLLA) nanoparticles loaded with retinyl palmitate	Nanoparticles of PLLA retinyl palmitate were developed with Pluronic F127, F68 and sodium dodecyl sulfate	Spherical PLLA- retinyl palmitate nanoparticles were prepared that possessed mean size of 40–110 nm with improved solubility and great retinyl palmitate loading.	[91]
RESOLV	Fenofibrate	Precipitation and stabilization as ultrafine particles of fenofibrate	The mean particle size was approximately 3 μm, which suggested improved solubility. The particles were found to be stable for 24 h.	[92]
GAS	Resveratrol [REMOVED HYPERLINK FIELD] and isoniazid, nicotinamide	Co-crystals of resveratrol were prepared with isoniazid and nicotinamide using CO2 antisolvent	The developed co-crystals exhibited enhanced bioavailability when compared to original resveratrol.	[93]
GAS	5-fluorouracil	Halloysite clay nanocarrier was developed to obtain high drug loading of 5-fluorouracil	Prepared nanocarrier loaded with 5-fluorouracil released significantly high drug release at pH 7.4 owing to improve solubility.	[94]
SSI	Quercetin	Quercetin was impregnated on Silica to enhance solubility	Several parameters i.e. temperature, time, pressure, and different cosolvents in the supercritical impregnation process were reported influential for quercetin solubility.	[95]
SSI	Promogran	Promogran was embedded on a spilanthol-enriched extract to modify solubility	Jambu extract that is completely soluble in fluid phase, was used to demonstrate enhanced solubility of promogran. A 4 h processing period was used for complete dissolution of the extract in SCF.	[96]
ASES	Irbesartan	Development of Irbesartan micro-particles and its composite micro-particles	Results highlighted modified solubility (7.5 times) and dissolution rate of Irbesatan microparticles compared to pure drug.	[97]
ASES	β-sitosterol	Preparation of submicroparticles of β-sitosterol	Powdered submicroparticles of β-sitosterol exhibited improved solubility.	[98]
ASES	Itraconazole	Preparation of solid-inclusion complexes of itraconazole with HP-β-CD	ASES-processed ITR-HP-β-CD inclusion complex solid powder showed 90% drug dissolution within 10 minutes.	[99]