Table 1.
Electrospun smart nanofibers applications.
| Smart System | Polymers | Drug | Application | Reference |
|---|---|---|---|---|
| pH-responsive | Eudragit S100, lecithin | Diclofenac sodium | Oral-colon targeted drug delivery. | [200] |
| Eudragit L100 | Alkaline phosphatase | Peroral delivery of proteins. | [201] | |
| Eudragit S, Eudragit RS | Indomethacin | Colonic drug delivery. | [202] | |
| Thermo-responsive | Poly(N-vinylcaprolactam-co-methacrylic acid) | Ketoprofen | Extended drug release. | [203] |
| Poly(di(ethylene glycol) methyl ether methacrylate), Ethyl cellulose | Ketoprofen | Extended drug release. | [204] | |
| Magnetic field-responsive | Poly (d,l-lactide-co-glycolide) | Bortezomib | Implantable device for endoscopic hyperthermia treatment and tumor-triggered controlled drug release. | [205] |
| Poly(ε-caprolactone) | Ketoconazole | Slow sustained release for fungal infections. | [206] | |
| Electrical field-responsive | Graphene, Poly(ε-caprolactone), Gelatin | Tetracycline hydrochloride | Neural tissue engineering and drug delivery. | [207] |
| Poly(ε-caprolactone) | Curcumin | Delivery through programmable electrical devices. | [208] | |
| Multi stimuli-responsive | Poly(N-vinylcaprolactam), Ethyl cellulose, Eudragit L100 | Ketoprofen | Dual temperature and pH-responsive delivery in lower intestinal tract. | [209] |
| Poly-N-isopropylacrylamide, chitosan | Curcumin | Dual temperature and pH-responsive for cancer targeting. | [210] |