Table 5. The estimated log Vdss values of the investigated compounds using equation 4 and their acid/base character.
| Drug name | Acid/base character | R20511-014-3 log Vdss | P20511-014-3 log Vdss | reference log Vdss |
|---|---|---|---|---|
| Acecainide | basic | -0.03 | -0.03 | 0.1 |
| Acetanilide | neutral | -0.12 | -0.12 | -0.13 |
| Acetazolamide | neutral | -0.47 | -0.47 | -0.46 |
| Alclofenac | acidic | -1.04 | -1.02 | -1.1 |
| Amoxapine | basic | 0.62 | 0.57 | 1.67 |
| Bamethan | basic | 0.01 | 0 | 0.01 |
| Betamethasone | neutral | 0.12 | 0.12 | 0.18 |
| Carbamazepine | neutral | -0.07 | -0.07 | -0.09 |
| Chlorpromazine | basic | 0.88 | 0.82 | 2.15 |
| Cinoxacin | acidic | -0.38 | -0.37 | -0.42 |
| Colchicine | neutral | 0.02 | 0.01 | 0.03 |
| Cytarabine | weak base | -0.26 | -0.26 | -0.31 |
| Diazoxide | weak acid | -0.19 | -0.19 | -0.16 |
| Diclofenac | acidic | -0.6 | -0.57 | -0.67 |
| Diprophylline | neutral | -0.22 | -0.23 | -0.24 |
| Ethinyl estradiol | neutral | 0.28 | 0.27 | 0.39 |
| Famotidine | weak base | -0.04 | -0.05 | -0.06 |
| Felbamate | neutral | 0.07 | 0.07 | -0.64 |
| Felodipine | neutral | 0.23 | 0.23 | 0.35 |
| Fenoprofen | acidic | -1.02 | -0.98 | -1.27 |
| Finasteride | neutral | 0.21 | 0.21 | 0.3 |
| Floxacillin | acidic | -0.55 | -0.53 | -0.56 |
| Flumazenil | neutral | -0.04 | -0.04 | -0.04 |
| Flurbiprofen | acidic | -1.44 | -1.42 | -1.56 |
| Furosemide | acidic | -0.7 | -0.68 | -0.71 |
| Gemfibrozil | acidic | -1.31 | -1.27 | -1.34 |
| Glipizide | acidic | -0.69 | -0.68 | -0.73 |
| Griseofulvin | neutral | 0.04 | 0.03 | 0.12 |
| Hydrochlorothiazide | weak acid | -0.18 | -0.17 | -0.13 |
| Hydrocortisone | neutral | 0.1 | 0.09 | 0.12 |
| Imipramine | basic | 0.66 | 0.6 | 1.16 |
| Indomethacin | acidic | -0.72 | -0.69 | -0.96 |
| Isradipine | neutral | 0.08 | 0.08 | 0.13 |
| Ketoconazole | weak base | 0.12 | 0.1 | 0.32 |
| Ketoprofen | acidic | -0.98 | -0.96 | -1.01 |
| Labetalol | amphoteric | 0.38 | 0.34 | 0.71 |
| Lignocaine | basic | 0.14 | 0.16 | 0.4 |
| Methylprednisolone | neutral | 0.12 | 0.11 | 0.16 |
| Metronidazole | weak base | -0.24 | -0.25 | -0.25 |
| Minoxidil | weak base | -0.11 | -0.1 | -0.04 |
| Nabumetone | neutral | -0.09 | -0.09 | 0.03 |
| Nadolol | basic | -0.34 | -0.35 | -0.33 |
| Nicardipine | weak base | 0.32 | 0.32 | 0.47 |
| Nifedipine | neutral | -0.07 | -0.07 | -0.04 |
| Nitrendipine | neutral | 0.08 | 0.08 | 0.16 |
| Papaverine | weak base | -0.13 | -0.13 | 0 |
| Pentoxifylline | neutral | -0.07 | -0.07 | -0.1 |
| Perphenazine | basic | 0.66 | 0.61 | 1.35 |
| Phenytoin | weak acid | -0.02 | -0.02 | 0.03 |
| Pindolol | basic | 0.14 | 0.13 | 0.85 |
| Prazosin | weak base | -0.11 | -0.13 | -0.05 |
| Prednisolone | neutral | 0.12 | 0.12 | 0.14 |
| Prednisone | neutral | 0.03 | 0.03 | 0.05 |
| Primidone | neutral | -0.13 | -0.13 | -0.15 |
| Probenecid | acidic | -0.66 | -0.64 | -0.75 |
| Procainamide | basic | -0.13 | -0.12 | 0.02 |
| Propanolol | basic | 0.64 | 0.59 | 1.29 |
| Propylthiouracil | weak acid | -0.31 | -0.31 | -0.34 |
| Proxyphylline | neutral | -0.75 | -0.74 | -0.85 |
| Sulfachlorpyridazine | acidic | -0.71 | -0.7 | -0.76 |
| Sulfameter | acidic | -0.57 | -0.57 | -0.61 |
| Sulfamethoxypyridazine | weak acid | -0.57 | -0.56 | -0.59 |
| Sulfinpyrazone | acidic | -0.64 | -0.62 | -0.65 |
| Sulfisoxazole | acidic | -0.68 | -0.67 | -0.72 |
| Sulphadimidine | amphoteric | -0.41 | -0.41 | 0.22 |
| Sulpiride | basic | -0.11 | -0.1 | 0.12 |
| Tamoxifen | basic | 0.94 | 0.89 | 1.48 |
| Theobromine | weak acid | -0.24 | -0.25 | -0.25 |
| Tolfenamic Acid | acidic | -0.54 | -0.49 | -0.76 |
| Trazodone | weak base | -0.09 | -0.1 | 0.01 |
| Trimethoprim | weak base | -0.05 | -0.06 | -0.06 |
| Warfarin | acidic | -0.69 | -0.68 | -0.78 |