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N-(3-dimethylaminopropyl)-N-ethylcarbo-diimide hydrochloride (EDC), N-hydroxy-succin-imide (NHS) synthesis of hyaluronanpropargyl-amide (hapa), followed by copper-catalysed azide-alkyne cycloaddition of hapa with azido-terminated poly(N-isopropylacrylamide) N3-PNIPAM (reprinted with the permission from [38]. Copyright (2010) American Chemical Society).
