Table 2. Membrane retention values of the neutral form of the drugs, obtained from skin-PAMPA assays with and without stirring at different incubation times.
| R M | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| With stirring | Without stirring | ||||||||
| Solutes | log Kp [18] | log Po/w [19] | pKa | 30 min | 4 h | 24 h | 30 min | 4 h | 24 h |
| 5-Fluorouracil | -6.82 | -0.89 | 7.86 a | 0.00 | 0.04(±0.04) | 0.08(±0.03) | 0.00 | 0.01(±0.03) | 0.05(±0.02) |
| Aminopyrine | -6.55 | 0.80 | 5.00 b | 0.00 | 0.00 | 0.05(±0.02) | 0.00 | 0.04(±0.01) | 0.05(±0.02) |
| Digitoxin | -8.15 | 2.83 | 0.00 | 0.22(±0.04) | 0.29(±0.05) | 0.00 | 0.09(±0.03) | 0.25(±0.02) | |
| Flurbiprofen | -4.72 | 4.16 | 4.19 c | 0.18(±0.03) | 0.00 | 0.00 | 0.13(±0.02) | 0.00 | 0.00 |
| Griseofulvin | -6.44 | 2.18 | 0.06(±0.01) | 0.19(±0.01) | 0.24(±0.02) | 0.03(±0.02) | 0.16(±0.01) | 0.20(±0.02) | |
| Hydrocortisone | -7.22 | 1.61 | 0.02(±0.00) | 0.01(±0.01) | 0.08(±0.03) | 0.00 | 0.04(±0.01) | 0.07(±0.02) | |
| Ibuprofen | -4.58 | 3.50 | 4.43 d | 0.22(±0.03) | 0.00 | 0.00 | 0.19(±0.07) | 0.09(±0.03) | 0.00 |
| Naproxen | -4.97 | 3.34 | 4.28 e | 0.13(±0.03) | 0.00 | 0.00 | 0.09(±0.02) | 0.04(±0.02) | 0.00 |
| Progesterone | -4.90 | 3.87 | 0.50(±0.04) | 0.74(±0.01) | 0.88(±0.01) | 0.33(±0.01) | 0.62(±0.04) | 0.83(±0.02) | |