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. 2021 Feb 26;2:627860. doi: 10.3389/fpain.2021.627860

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Copyright © 2021 Miyahara, Nishimaru, Matsumoto, Setogawa, Taguchi, Ono and Nishijo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of repeated reserpine injection on PV-positive neurons in S1. (A,B) Photomicrographs of the mice S1 in the VEH (A) and RES (B) groups. Insets in (a) are shown in (b) as enlarged views. The number of PV-positive neurons was increased in the RES group. S1HL, S1 hindlimb area; S1FL, S1 forelimb area. (C) Comparison of the PV-positive neuron density in the S1FL (a), S1HL (b), and S1L (c) between the VEH and RES groups. S1FL, S1 forelimb area; S1HL, S1 hindlimb area; S1L, S1 leg area (mean of S1FL and S1HL). ^***p < 0.001 (Welch's test). Open circles, VEH group; filled circles, RES group. Numbers in parentheses indicate the number of animals.