TABLE 2.
Allele and genotype distribution frequencies of SNPs in the case and control groups.
| SNP | Model | Case | Control | X2 | OR (95%CI) | p-value |
|---|---|---|---|---|---|---|
| rs895819 | Allele A | 320 (73) | 252 (57) | 22.38 | 0.50 (0.38–0.67) | p < 0.001 |
| Allele G | 120 (27) | 188 (43) | ||||
| Co-dominant (AG v AA+GG) | 96 (44) | 100 (45) | 24.88 | 0.92 (0.63–1.35) | p < 0.001 | |
| Dominant (AA v AG+GG) | 112 (51) | 76 (35) | 11.39 | 0.51 (0.35–0.76) | 0.001 | |
| Recessive (GG v AA+AG) | 12 (5) | 44 (20) | 20.95 | 0.23 (0.11–0.45) | p < 0.001 | |
| † = 0.13 | ¥ = 0.29 | |||||
| rs531564 | Allele G | 288 (65.5) | 288 (65.5) | 0.02 | 1.02 (0.77–1.34) | 0.88 |
| Allele C | 152 (34.5) | 152 (34.5) | ||||
| Co-dominant (GC v GG+CC) | 106 (48) | 92 (43) | 2.01 | 1.29 (0.88–1.88) | 0.36 | |
| Dominant (GG v GC+CC) | 91 (43) | 98 (44.5) | 0.59 | 1.16 (0.79–1.69) | 0.44 | |
| Recessive (CC v GG+GC) | 23 (11) | 30 (14) | 0.78 | 0.76 (0.43–1.37) | 0.37 | |
| † = 0.33 | ¥ = 0.26 | |||||
| rs6505162 | Allele A | 275 (62.5) | 327 (74) | 16.36 | 1.80 (1.35–2.40) | p < 0.001 |
| Allele C | 165 (37.5) | 113 (26) | ||||
| Co-dominant (AC v AA+CC) | 115 (52) | 89 (40) | 17.16 | 1.35 (0.93–1.96) | p < 0.001 | |
| Dominant (AA v AC+CC) | 80 (36) | 119 (54) | 15.45 | 2.14 (1.46–3.14) | p < 0.001 | |
| Recessive (CC v AA+AC) | 25 (11) | 12 (5) | 6.33 | 2.42 (1.19–4.92) | 0.012 | |
| † = 0.08 | ¥ = 0.37 |
†Indicates HWB p-value for cases. ¥Indicates HWB p-value for controls.
Bold values are statistically significant values p<0.05.