TABLE 2.
Laboratory data of the studied groups.
| Controls (n = 147) | Disease severity | J-T | Effect size (CI 95%) | p Value | |||
|---|---|---|---|---|---|---|---|
| Mild (no = 116) | Moderate (n = 128) | Severe (n = 55) | |||||
| Hb(g/l) | 127 ± 18 | 125 ± 15 | 128 ± 20 | 119 ± 19 | 0.83 | −0.03 (−0.10 to 0.04) | 0.403 |
| RBCs*106 | 5.0 ± 0.4 | 5.0 ± 1.6 | 5.1 ± 1.9 | 4.7 ± 1.8 | 1.73 | −0.15 (−0.22) to (−0.07) | <0.001 |
| HCT% | 42.1 ± 3.7 | 38.3 ± 6.0 | 38.2 ± 8.1 | 36.8 ± 8.3 | 0.08 | −0.16 (−0.23) to (− 0.09) | <0.001 |
| Platelets*103 | 322 (257–371) | 209.5 (176–277.5) | 215 (162–248.7) | 188 (120–245) | 2.87 | −0.38 (−0.44) to (−0.32) | <0.001 |
| WBCs*103 | 6.3 (4.9–7.1) | 5.9 (4.8–7.2) | 5.7 (3.6–7.5) | 5.5 (3.4–10.6) | 0.77 | −0.04 (−0.09) to ( 0.04) | 0.232 |
| Lymphocytes*103 | 1.7 (1.5–2.4) | 1.5 (1.1–2.1) | 1.1 (0.6–1.6) | 0.8 (0.5–1.1) | 9.39 | −0.35 (−0.41) to (−0.29) | <0.001 |
| Neutrophils*103 | 3.7 (3.0–4.6) | 3.7 (2.8–5.8) | 2.5 (1.5–3.1) | 3.1 (2.2–7.6) | 5.85 | −0.18 (−0.25) to (−0.11) | <0.001 |
| NLR | 2.1 (1.6–2.6) | 2.6 (1.6–3.7) | 2.3 (1.5–3.5) | 3.9 (2.6–8.8) | 3.08 | 0.19 (0.13) to (0.26) | <0.001 |
| PLR | 10.2 (8.5–12.7) | 9.4 (5.3–13.5) | 10.7 (6.3–15.10 | 12.2 (7.6–20.1) | 3.18 | 0.06 (−0.001) to (0.13) | 0.077 |
| CRP (mg/L) | 2.3 (1.4–3.5) | 13.8 (6.8–28) | 70 (25.7–190) | 114 (82.9–150.20 | 11.19 | 0.70 (0.67–0.72) | <0.001 |
| Ferritin (mg/L) | 17 (12–25) | 120 (61.3–199) | 257.5 (132–645.5) | 612.0 (345.6–831) | 9.26 | 0.67 (0.63–0.70) | <0.001 |
| LDH (mg/L) | 285 (248–321) | 336.5 (250–388.5) | 334.5 (250.8–600) | 381.0 (280–776) | 2.47 | 0.22 (0.15–0.28) | <0.001 |
| D-Dimer (mg/L) | 100 (100–180) | 245 (140–530) | 310 (140–786.3) | 430 (200–1210) | 2.74 | 0.38 (0.32–0.44) | <0.001 |
Data are expressed as Mean ± SD or Median (Interquartile range). Linear trend analysis using the Jonckheere-Terpstra test was applied to detect whether there was an increasing or decreasing trend across the ordered groups. Effect size was estimated using Mann-Kendall (M-K) test to detect the presence of linear or non-linear trends (steadily increasing/decreasing or unchanging) in a series of data following Jonckheere-Terpstra (J-T) Test.
CI 95%, Confidence interval at 95%; Hb, Hemoglobin; RBCs, Red blood cells; HCT, Hematocrit; WBCs, white blood cells, lymphocytes and neutrophils were presented in absolute figures; NLR, Neutrophil lymphocyte ratio; PLR, Platelets lymphocyte ratio; CRP, C- reactive protein; LDH, lactate dehydrogenase.