TABLE 7.
Distribution of associated symptoms according to ACE2 and TMPRSS2 SNPs.
| Symptoms | ACE2 (rs2285666) | p Value | TMPRSS2 (rs12329760) | p Value | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CC (no = 196) | CT + TT (n = 103) | CC (no = 236) | CT + TT (n = 63) | ||||||||||
| No | % | No | % | No | % | No | % | ||||||
| Fever | 148 | 75.5 | 92 | 89.3 | 0.004 | 179 | 75.8 | 61 | 96.8 | <0.001 | |||
| Cough | 156 | 79.6 | 92 | 89.3 | 0.034 | 189 | 80.1 | 59 | 93.7 | 0.011 | |||
| Sore throat | 33 | 16.8 | 52 | 50.5 | <0.001 | 62 | 26.3 | 23 | 36.5 | 0.110 | |||
| Muscle ache | 79 | 40.3 | 59 | 57.3 | 0.005 | 104 | 44.1 | 34 | 54.0 | 0.161 | |||
| Headache | 87 | 44.4 | 67 | 65.0 | 0.001 | 110 | 46.6 | 44 | 69.8 | 0.001 | |||
| Dyspnea | 55 | 28.1 | 57 | 55.3 | <0.001 | 78 | 33.1 | 34 | 54.0 | 0.002 | |||
| Diarrhea | 32 | 16.3 | 13 | 12.6 | 0.395 | 26 | 11.0 | 19 | 30.2 | <0.001 | |||
| Loss of taste | 60 | 30.6 | 36 | 35.0 | 0.445 | 71 | 30.1 | 25 | 39.7 | 0.147 | |||
| Loss of smell | 94 | 48.0 | 51 | 49.5 | 0.798 | 116 | 49.2 | 29 | 46.0 | 0.660 | |||
Data are expressed as no, %, Chi-square test (χ2) was used as a test of significance.
ACE2, Angiotensin converting enzyme 2; TMPRSS2, Transmembrane serine protease 2; C, cytosine; T, thymine.