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. 2021 Jul 22;2:683168. doi: 10.3389/fpain.2021.683168

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Copyright © 2021 Warncke, Toma, Meade, Park, Thompson, Caillaud, Bigbee, Bryant and Damaj.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reduction of intraepidermal nerve fiber density in the hind paw at week 11. (A) shows C57BL/6J males and females (n = 6/group), while changes to IENF density in BALB/cJ males and females (n = 6/group) are shown in (B). Representative fluorescence microscopic images of IENF taken at 40X (C). Values are expressed as mean ± SEM. Overall effects of oxaliplatin treatment per sex of each strain were identified using one-way ANOVA Treatment) for each strain and for each sex, and post-hoc Dunnet's test (*p < 0.05; **p < 0.001; ***p < 0.0001).