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. 2021 Jul 22;2:683168. doi: 10.3389/fpain.2021.683168

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Copyright © 2021 Warncke, Toma, Meade, Park, Thompson, Caillaud, Bigbee, Bryant and Damaj.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Induction of mechanical and cold hypersensitivity by low and high dose of oxaliplatin. Development of mechanical hypersensitive was monitored after each regimen of oxaliplatin (5 injections of 0.3 or 3 mg/kg) with the von Frey test in C57BL/6J males (n = 17/group) (A), C57BL/6J females (n = 11/group) (B), BALB/cJ males (n = 7–9/group) (C), BALB/cJ females (n = 10/group) (D). Similarly, cold hypersensitivity was tested on the same week in in C57BL/6J males (n = 8/group) (E), C57BL/6J females (n = 8/group) (F). Values are expressed as mean ± SEM. Results were compared using two-way ANOVA (Treatment, Time as RM) for each strain and for each sex followed by Tukey's post-hoc test, p < 0.05. Filled points indicate times at which mechanical hypersensitivity was statistically different from vehicle. *p < 0.05 high vs. low dose.