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. 2021 Jul 22;2:683168. doi: 10.3389/fpain.2021.683168

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Copyright © 2021 Warncke, Toma, Meade, Park, Thompson, Caillaud, Bigbee, Bryant and Damaj.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High dose of oxaliplatin reduce spontaneous locomotor activity in C57BL/6J mice. One regimen of the high dose of oxaliplatin was sufficient to reduce locomotor activity in C57BL/6J males (n = 8–10/group) (A) which continued 1 week after the treatment. C57BL/6J females (n = 6–8/group). (B) showed lower activity after two regimens. No alteration in motor coordination was obsessed in BALB/cJ males (n = 7–9/group) (C) nor females (n = 10/group) (D). Overall effects of oxaliplatin treatment were identified by two-way or mixed-analysis model ANOVA (Treatment, Time as RM) for each strain and for each sex with post-hoc Tukey's multiple comparisons test, *p < 0.05.