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. 2021 Jul 22;2:683168. doi: 10.3389/fpain.2021.683168

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Copyright © 2021 Warncke, Toma, Meade, Park, Thompson, Caillaud, Bigbee, Bryant and Damaj.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decrease in time spend in the light area after oxaliplatin exposure. Anxiety-like behavior was assessed in C57BL/6J males (Cohort 1, BL and week 3, n = 9/group; Cohort 2, week 4 and week 7, n = 8/group) (A), C57BL/6J females (Cohort 1, BL and week 3, n = 9/group; Cohort 2, week 4 and week 7, n = 8/group) (B), BALB/cJ males (n = 7–9/group) (C), BALB/cJ females (n = 10/group) (D). Values are expressed as mean ± SEM. Overall effects of oxaliplatin treatment were identified by two-way mixed-analysis model ANOVA (Treatment, Time as RM) for each strain and for each sex ANOVA with post-hoc Tukey's multiple comparisons test, *p < 0.05; **p < 0.001.