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Brain regions involved in underlying mechanisms of migraine and reported alterations. Modulation of incoming noxious inputs: spinal trigeminal nucleus (SpV), periaqueductal gray matter (PAG), rostral ventromedial medulla (RVM) and dorsal pons. Higher order processing: hypothalamus, thalamus, anterior cingulate cortex (ACC), insula and primary somatosensory cortex (S1).
