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. 2021 Oct 22;2:731658. doi: 10.3389/fpain.2021.731658

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Copyright © 2021 Shillo, Yiangou, Donatien, Greig, Selvarajah, Wilkinson, Anand and Tesfaye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(a) von Willebrand Factor (vWF) immunoreactivity in calfskin from healthy volunteers, HV (b), painful-DPN (c) painless-DPN, (d) No-DPN, (e) image analysis of vWF sub-epithelial endothelial staining (% immunoreactivity).