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. 2022 Mar 3;119(10):e2113329119. doi: 10.1073/pnas.2113329119

Fig. 7.

Fig. 7.

The CD73 pathway suppresses Ova-specific CD8+ T cell responses early after Listeria infection in vivo. (A) C57BL/6 mice infected with L. monocytogenes ΔactA-Ova. Absolute number of Ova-specific CD8+ T cells at 7 d postinfection in spleens with control and early (days 0 to 2) versus late (days 5 to 6) TGF-β and CD73 single and dual blockade compared (n = 4 per group). (B) Percent and absolute number of splenic Ova-specific CD8+ T cells at day 7 after L. monocytogenes ΔactA-Ova infection of C57BL/6 versus Foxp3DTR-eGFP mice. DT injection dictated specific Treg depletion with control and late (days 5 to 6) TGF-β and CD73 single and dual blockade compared (n = 4 per group). (C) Proposed model for biphasic Treg response to L. monocytogenes infection. Numbers in scatterplots represent percentage. Mean ± SEM. (A) *P < 0.05 and **P < 0.01 (Student’s t test); (A and B) †P < 0.05, ††P < 0.01, and ††††P < 0.0001 (one-way ANOVA relative to negative control).