Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 15;3:824825. doi: 10.3389/ftox.2021.824825

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Koning, Rodrigues Neves, Schimek, Thon, Spiekstra, Waaijman, de Gruijl and Gibbs.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Detection of nickel ions and interleukins. (A) Detection of the amount of nickel ions in culture supernatants derived from HUMIMIC Chip3plus, measured with graphite furnace atomic absorption spectrometry (GFAAS) in both vehicle (V)- and nickel (N)-exposed co-cultures at day 3. (B-D) Quantification of IL-6 (B), IL-8 (C), and IL-18 (D) in supernatants of multi-organ cultures upon exposure to the vehicle (V) or NiSO4 (N) over 3 days of culturing. The data represent mean ± SEM; n = 3. *, p < 0.05; paired t-test (A), 2-way ANOVA followed by Bonferroni’s multiple comparison test (B–D).