TABLE 3.

Functional annotation analysis of community clusters identified from network analysis. Communities 1, 5 and 15, were identified as key clusters within the Human Protein-Protein Interactome that was overrepresented with DARTable and MIE genes (Figure 3). Genes from each community was evaluated for GO-BP overrepresentation (FDR<0.05). Key over-represented GB-BP are reported in the table and the gene lists can be found in Supplementary File S3. The Count is the number of genes in the Community annotated with the GO-BP, % is the percentage of input genes annotated with the term compared to the annotated genes with the term. Fold enrichment is the ratio between the background frequency of total genes annotated to that term to the input gene list for the term.

Community	Term	FDR	Count	%	Fold enrichment
Community 1	Regulation of transcription, DNA-templated	3.31E-48	742	27.6	1.61
	Keratinization	1.13E-05	23	0.9	3.61
	Cell fate commitment	4.27E-03	55	2.0	1.77
	Embryo development	1.26E-02	162	6.0	1.33
Community 5	Intracellular signal transduction	5.35E-75	740	26.2	1.85
	Phosphorylation	2.27E-69	642	22.7	1.91
	Cell cycle	1.41E-42	463	16.4	1.84
	Cell projection organization	5.20E-39	378	13.4	1.93
	Cell migration	3.97E-26	319	11.3	1.79
	Cilium organization	7.05E-17	89	3.2	2.60
Community 15	Transmembrane transport	1.80E-74	503	15.0	2.19
	Ion transport	5.09E-72	532	15.9	2.10
	Chemical homeostasis	6.68E-35	348	10.4	1.91
	Lipid metabolic process	1.48E-27	392	11.7	1.70
	Inorganic ion transmembrane transport	2.55E-27	250	7.5	1.99
	Sphingolipid biosynthetic process	5.63E-16	56	1.7	3.29
	Protein exit from endoplasmic reticulum	6.42E-10	28	0.8	3.93
	GPCR signaling pathway, coupled to cyclic nucleotide second messenger	2.31E-07	68	2.0	2.03
	Cyclic purine nucleotide metabolic process	1.46E-06	54	1.6	2.13