TABLE 4.
Using the DARTable Genome to Identify the Relevant Cell lines. Seven cell lines were ranked by the number of HDG genes they express that meet the selection criterion. The top scoring cell line was then selected for the panel and the remaining cell lines were then re-ranked, based on how many HDG genes that met the selection criteria were not already covered by the cell line(s) already selected for the panel. For each cell line in each iteration, we show the number of additional HDG with above per average gene expression that cell line would add and the cell lines ranking in parentheses.
| Cell line | Iteration | |||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | |
| RD | 2,330 (1) | |||||
| OVCAR-3 | 2,100 (2) | 1,197 (1) | ||||
| THP-1 | 1966 (3) | 1,022 (3) | 650 (1) | |||
| A549 | 1,562 (6) | 918 (4) | 531 (=3) | 388 (1) | ||
| Hep G2 | 1,210 (7) | 736 (6) | 531 (=3) | 369 (3) | 248 (1) | |
| MCF7 | 1785 (4) | 1,128 (2) | 630 (2) | 386 (2) | 229 (2) | 148 (1) |
| ACHN | 1,699 (5) | 902 (5) | 529 (5) | 361 (4) | 159 (3) | 106 (2) |