TABLE 1.
Comparison of human IBD with cIBD in dogs and traditional rodent models of IBD.
| Feature | Humans | Canines | Rodents |
|---|---|---|---|
| Genetic basis | Yes | Yes | Engineered |
| Etiology | Multifactorial | Multifactorial | +/- multifactorial |
| Intact immune system | Yes | Yes | +/- |
| Role of GI microbiota | Yes | Yes | Yes |
| Blood in stool | Yes | Yes | Yes |
| Diarrhea | Yes | Yes | Yes |
| Definitive diagnosis | GI mucosal biopsy | GI mucosal biopsy | GI mucosal biopsy |
| Longitudinal studies | Yes–endoscopy, histology | Yes–endoscopy, histology | No |
| IBD treatment | Diet + drugs | Diet + drugs | Drugs |
| Disease heterogeneity | Yes | Yes | Variable |