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. 2021 Mar 22;3:636976. doi: 10.3389/ftox.2021.636976

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Copyright © 2021 Dussert, Wegner, Moriscot, Gallet, Jouneau, Reiss and Carriere.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intracellular distribution of pristine thick shell quantum dots (QDs) in keratinocytes, observed by transmission electron microscope (TEM) and scanning-transmission electron microscope (STEM) imaging, coupled to energy-dispersive X-ray spectroscopy (EDX) analysis. Control cells (unexposed) (A), cells exposed for 24 h to 50 nM of pristine thick shell QD [(B–D), white arrows in panel (B): agglomerates of QDs]. High-angle annular dark-field imaging (HAADF) mapping of a cell exposed to 50 nM of pristine thick-shell QD (E) and EDX analysis of the areas 1 (red) and 2 (black dashed) of this image (F), with image representation of the distribution of Zn (G), In (H), Se (I), P (J), and S (K). n, nucleus; c, cytoplasm.