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. 2021 Oct 8;3:705910. doi: 10.3389/ftox.2021.705910

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Copyright © 2021 Tachibana, Kawazoe, Onoda, Umezawa and Takeda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The number of differentially expressed genes with altered DNA methylation following TiO₂-NP exposure.—Venn diagram analysis whether differentially expressed genes are accompanied by alteration of DNA methylation. Venn diagram showing the number of differentially expressed genes with altered DNA methylation following TiO₂-NP (Sham vs. TiO₂-H) in the brains of 1-day-old offspring mice [(A): male, (B): female]. The DNA methylation state and expression level of genes were identified by Mouse CpG Island Microarray and SurePrint G3 Mouse GE 8 × 60 K Microarray, respectively.