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. 2021 Jul 6;3:653569. doi: 10.3389/ftox.2021.653569

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Copyright © 2021 Guerrina, Traboulsi, Eidelman and Baglole.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BAL cytokines are similar between chronic 4-month cigarette smoke-exposed Ahr^+/− and Ahr^−/− mice. Ahr^+/− and Ahr^−/− mice were exposed to a 4-month CS regime and cytokines analyzed in the BAL fluid by multiplex analysis. (A) Neutrophils- there was an overall increase in the levels of CXCL1, IL-6, TNF-α and G-CSF after 4 months of CS exposure (*p < 0.05, **p < 0.01 compared to corresponding air-control); there was no significant difference (ns) between smoke-exposed Ahr^+/− and Ahr^−/− mice. (B) Monocyte/macrophage- although CS generally increased BAL levels of CCL2, CCL3, and CCL4, there was no significant difference between Ahr^+/− and Ahr^−/− mice. (C) Lymphocytes- there was no significant change in CXCL10 or IL-17 in response to CS. Results are shown as means ± SEM (n = 4–5 mice per group); 2-way ANOVA followed by the Neuman-Keuls multiple comparisons test.

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