TABLE 1.
Physiological parameters and Kp,app of KNI-272 in various rat tissues after i.v. administration to rats at 10.0 mg/kg
| Tissue | Q (ml/min)a | V (ml)a | Kp,appb |
|---|---|---|---|
| Lung | 43.00 | 1.0 | 0.92 |
| Brain | 1.33 | 1.7 | 0.44 |
| Heart | 3.92 | 0.8 | 0.24 |
| Liver | 11.80c | 10.3 | 5.72 |
| Kidney | 9.23 | 2.3 | 4.12 |
| Stomach | 1.14 | 1.1 | 2.36 |
| Spleen | 0.63 | 0.6 | 0.53 |
| Small intestine | 7.52 | 10.0 | 7.53 |
| Adipose tissue | 0.40 | 10.0 | 2.29 |
| Skeletal muscle | 7.50 | 121.9 | ND |
a
Values for Q and V are those observed by Bernareggi et al. for a 250-g rat (6).
b
Each value is the mean from three experiments. ND, not detected.
c
Sum of hepatic artery plus portal vein flow.