Fig. 1.

Mature HIV-1 capsids are pleomorphic. (A) Fullerene geometries for the HIV-1 capsid were derived from cryo-ET images of intact virions (16). Atomic models for the capsid contain either (B) liquid water in the capsid interior, (C) a ribonucleoprotein (RNP) complex model, (D) IP₆ molecules bound to the capsid pores, or (E) both the RNP and IP₆. The CA NTD and CTD are colored in green and brown, whereas genomic RNA, nucleocapsid proteins, and IP₆ molecules are in purple, teal, and orange, respectively. Pentamer defects are colored in red.