FIGURE 3.

Schematic representation of the major components of the atherogenic dyslipidemia typical of patients displaying type 2 diabetes with poor glycemic control. This dyslipidemia features hypertriglyceridemia involving elevated levels of VLDLs and remnants, a predominance of small, cholesterol-poor dense LDL in the LDL particle profile and subnormal levels of HDL and apoAI which exhibit impaired functionality. Elevated flux of free fatty acids from adipose tissue to the liver as a result of peripheral insulin resistance in type 2 diabetes are a major metabolic driver of hepatic VLDL production and thus of this dyslipidemic phenotype.