The revolution in structural biology isn’t attributable to AI alone; the algorithms have to train on big datasets of high-resolution crystal structures generated by technologies such as nuclear magnetic resonance spectroscopy or cryogenic electron microscopy (cryo-EM), which produced the above image of a protein complex called β-galactosidase. Image credit: Veronica Falconieri and Sriram Subramaniam (National Cancer Institute, Bethesda, MD).