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. 2022 Feb 25;9:851255. doi: 10.3389/fnut.2022.851255

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Copyright © 2022 Chen, Huang, Bian and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Berberine inhibited the inflammatory cytokines in C57BL/6 mice with ALI. (A) The expression of reactive oxygen species (ROS) in pulmonary section and its quantification (down), n = 3, scale bar = 20 μm. (B) The messager RNA (mRNA) expression of IL-6, TNF-α, and IL-10 in lung tissue, n = 8. (C) The concentration of IL-6, TNF-α, and IL-10 in lung tissue, n = 8. (D) The expression of IL-18 in lung section, n = 3, bar = 20 μm. (E) The concentration of IL-18 and IL-1β in lung tissue, n = 8. Data were expressed as mean ± SD. Statistical significance is indicated as *P < 0.05 vs. the sham + vehicle groups, ^#P < 0.05 vs. the LPS + vehicle groups.