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. 2022 Feb 25;9:851255. doi: 10.3389/fnut.2022.851255

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Copyright © 2022 Chen, Huang, Bian and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Berberine regulated the expression of phosphorylated NF-κB and Nlrp3 in mice with ALI. (A) The expression of Nlrp3 and p-NF-κB at protein level in lung tissue, n = 6. (B) The mRNA expression of Nlrp3 in vivo, n = 8. (C) The mRNA expression of Nlrp3 in vitro, n = 3. (D) The mRNA expression of IL-1β and IL-18 in lung tissue, n = 8. (E) The mRNA expression of IL-1β and IL-18 in HPMECs, n = 3. Data were expressed as mean ± SD. Statistical significance is indicated as *P < 0.05 vs. the sham + vehicle groups, ^#P < 0.05 vs. the LPS + vehicle groups.